827614-70-0 | 3,4,5-TRIFLUOROPHENYLBORONIC ACID, PINACOL ESTER

CAS:827614-70-0 | 3,4,5-TRIFLUOROPHENYLBORONIC ACID, PINACOL ESTER,Description

4,4,5,5-Tetramethyl-2-(3,4,5-trifluorophenyl)-1,3,2-dioxaborolane is a chemical compound used for experimental and research purposes. It is also known as 3,4,5-Trifluorophenylboronic Acid Pinacol Ester.

Molecular Structure Analysis

The molecular formula of this compound is C12H14BF3O2. The structure includes a boron atom connected to an oxygen ring structure (dioxaborolane), which is further connected to a trifluorophenyl group.

Physical And Chemical Properties Analysis

This compound is a liquid at 20 degrees Celsius. It has a molecular weight of 258.05 g/mol. The compound is colorless to light yellow and clear in appearance. It has a specific gravity of 1.17 at 20/20 degrees and a refractive index of 1.45. The flash point of the compound is 126 °C.

Scientific Research Applications

Synthesis and Applications in Organic Chemistry

• A novel series of 4,4,5,5-tetramethyl-2-(4-substitutedstyrylphenyl)-1,3,2 dioxaborolane derivatives have been synthesized, showing potential in synthesizing boron-containing polyene systems for new material applications, such as Liquid Crystal Display (LCD) technology. These compounds are also being explored for their therapeutic potential in neurodegenerative diseases (Das, Mahalingam, Das, Hosmane, & Evans, 2015).
• The development of a scalable process for preparing 4,4,5,5-tetramethyl-2-(3-trimethylsilyl-2-propynyl)-1,3,2-dioxaborolane is significant, addressing challenges in production and implementing a continuous-flow and distillation process to efficiently produce a key propargylation reagent (Fandrick, Roschangar, Kim, Hahm, Cha, Kim, Yoo, Kim, Reeves, Song, Tan, Qu, Haddad, Shen, Grinberg, Lee, Yee, & Senanayake, 2012).
• Research into the development of new building blocks for silicon-based drugs and odorants, like the synthesis of the retinoid agonist disila-bexarotene, demonstrates the compound's utility in creating biologically active derivatives (Büttner, Nätscher, Burschka, & Tacke, 2007) .

Applications in Biological and Medical Research

• In medical research, specific boron-containing stilbene derivatives synthesized from 4,4,5,5-tetramethyl-2-(4-substitutedstyrylphenyl)-1,3,2 dioxaborolane have shown potential as lipogenesis inhibitors, which can suppress lipogenic gene expression in mammalian hepatocytes and cholesterol biosynthesis. This opens avenues for developing new lipid-lowering drugs (Das, Zhao, Tang, & Yang, 2011).

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