723286-98-4 | 2-(Chloromethyl)-5-(trifluoromethyl)-1,3,4-oxadiazole

CAS:723286-98-4 | 2-(Chloromethyl)-5-(trifluoromethyl)-1,3,4-oxadiazole ,Description

2-(Chloromethyl)-5-(trifluoromethyl)-1,3,4-oxadiazole (CMTF) is a heterocyclic compound that is widely used in scientific research due to its unique properties. It is a colorless solid compound with a melting point of 72-76 °C and a boiling point of 161-164 °C. CMTF is a widely used organic compound due to its high reactivity, low toxicity, and low cost. It is used in a variety of applications, including organic synthesis, drug design, and biological research.
 

Scientific Research Applications

• Chiriac, Tanasă, and Nechifor (2012) presented an efficient one-pot synthesis of 2,5-diaryl-1,3,4-oxadiazoles, with potential applications in analgesics, herbicidal, muscle relaxants, and organic light-emitting diodes (Chiriac, Tanasă, & Nechifor, 2012) .
• Milinkevich et al. (2009) found that 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles show potential as effective antifungal and pest insect treatments for crops (Milinkevich et al., 2009).
• Zhang, Qian, and Li (1999) developed a novel synthetic route to 2-amino-5-aryl-1,3,4-oxadiazoles containing trifluoroethoxy groups (Zhang, Qian, & Li, 1999).
• Hutt, Elslager, and Werbel (1970) demonstrated the potential of 2-phenyl-5-(trichloromethyl)-1,3,4-oxadiazoles as a new class of antimalarial agents (Hutt, Elslager, & Werbel, 1970).
• Tong (2011) noted that 2-Chloromethyl-5-aryl-1,3,4-Oxadiazole compounds exhibit strong purple fluorescence in DMF solution, making them promising as purple luminescent materials (Tong, 2011).
• Kiss-Szikszai, Patonay, and Jekoe (2001) synthesized substituted 2-aryl-5-aminomethyl- and -5-thiomethyl-1,3,4-oxadiazoles, which were oxidized into 5-sulfinylmethyl and 5-sulfonylmethyl-1,3,4-oxadiazoles (Kiss-Szikszai, Patonay, & Jekoe, 2001).
• Shi, Qian, Zhang, and Song (2001) found new 2,5-disubstituted-1,3,4-oxadiazoles exhibiting good insecticidal activities against armyworm larvae (Shi, Qian, Zhang, & Song, 2001).
• Maftei, Fodor, Jones, Daniliuc, Franz, Kelter, Fiebig, Tamm, and Neda (2016) demonstrated potential anti-cancer activity in novel 1,2,4-oxadiazole and trifluoromethylpyridine derivatives (Maftei et al., 2016).
• Parra, Hidalgo, Carrasco, Barberá, and Silvino (2006) explored the synthesis and luminescence properties of new 1,2,4‐ and 1,3,4‐oxadiazole materials, suggesting applications in photoluminescence and emissive reduction (Parra, Hidalgo, Carrasco, Barberá, & Silvino, 2006) .

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