496807-97-7 | 3,3-DIFLUOROPIPERIDINE HYDROCHLORIDE

CAS:496807-97-7 | 3,3-DIFLUOROPIPERIDINE HYDROCHLORIDE,Description

3,3-Difluoropiperidine hydrochloride is a hydrochloride salt of piperidine with two fluoride substituents at the 3-position. It’s a building block used in the synthesis of various compounds.

Molecular Structure Analysis

The molecular formula of 3,3-Difluoropiperidine hydrochloride is C5H9F2N·HCl. The molecular weight is 157.59 g/mol.

Chemical Reactions Analysis

3,3-Difluoropiperidine hydrochloride can be used as a building block in the synthesis of various compounds, including triazole substituted prolyl difluoropyrrolidines as potential inhibitors of dipeptidyl peptidase-4 and dual leucine zipper kinase (DLK) inhibitors.

Physical And Chemical Properties Analysis

3,3-Difluoropiperidine hydrochloride is a solid substance. It has a melting point of 243-247 °C.

Scientific Research Applications

• Organic Synthesis

  • “3,3-Difluoropiperidine hydrochloride” is a type of fluorinated building block, which means it’s likely used in the field of organic chemistry for the synthesis of various compounds. The exact applications, methods of use, and results obtained are not specified in the sources I found.

• Buchwald-Hartwig Amination

  • It appears that “3,3-Difluoropiperidine hydrochloride” might be used in Buchwald-Hartwig Amination. This is a type of chemical reaction used to form carbon-nitrogen bonds. The exact details of this application are not provided in the source.

• Cancer Research

  • There is a mention of “3,3-difluoropiperidine hydrochloride” having an enhanced selectivity of estrogen positive breast cancer. This suggests that it might be used in cancer research, particularly in the study of breast cancer. The exact methods of application and results obtained are not specified in the source.

• NMR Probing

  • “3,3-difluoropiperidine hydrochloride” is also used as a 19 F NMR probe without requiring deuterated solvents or internal standards. This suggests that it might be used in the field of nuclear magnetic resonance (NMR) spectroscopy, a technique used to obtain information about the structure and dynamics of molecules.

• Triazole Substituted Prolyl Difluoropyrrolidines

  • “3,3-Difluoropiperidine hydrochloride” might be used in the synthesis of triazole substituted prolyl difluoropyrrolidines. These compounds could potentially serve as inhibitors of dipeptidyl peptidase-4, an enzyme that plays a role in glucose metabolism and is a target for the treatment of type 2 diabetes.

• Dual Leucine Zipper Kinase (DLK) Inhibitors

  • It appears that “3,3-Difluoropiperidine hydrochloride” might be used in the synthesis of DLK inhibitors. DLK is a protein kinase involved in neuronal development and degeneration, and inhibitors of this enzyme could potentially be used in the treatment of neurodegenerative diseases.

• Preparation of Cyclic and Acyclic β-Aminofluoroalkenes

  • “3,3-Difluoropiperidine hydrochloride” might be used as a reactant in the preparation of cyclic and acyclic β-aminofluoroalkenes via allylic amination using a palladium catalyst. These compounds could have various applications in medicinal chemistry.

Safety And Hazards

This compound may cause skin and eye irritation, and may be harmful if inhaled. It’s recommended to use personal protective equipment and ensure adequate ventilation when handling this chemical.

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