2613-23-2 | 3-Chloro-4-fluorophenol

CAS:2613-23-2 | 3-Chloro-4-fluorophenol,Description

3-Chloro-4-fluorophenol is a halophenol and an organofluorine compound. It has been used in the preparation of 3-chloro-4-fluoro-2′-methoxycarbonyldiphenyl ether required for the synthesis of flavone and xanthone derivatives.

Molecular Structure Analysis

The molecular formula of 3-Chloro-4-fluorophenol is C6H4ClFO. Its molecular weight is 146.55. The structure can be represented by the SMILES string Oc1ccc(F)c(Cl)c1.

Physical And Chemical Properties Analysis

3-Chloro-4-fluorophenol is a solid substance. It has a boiling point of 104 °C at 11 mmHg and a melting point of 38-40 °C. It is slightly soluble in water and soluble in most common organic solvents.

Scientific Research Applications

Synthesis of Flavone and Xanthone Derivatives

• Application Summary : 3-Chloro-4-fluorophenol is used in the preparation of 3-chloro-4-fluoro-2′-methoxycarbonyldiphenyl ether, which is required for the synthesis of flavone and xanthone derivatives.

Sono-Photochemical Properties of Zinc Phthalocyanine/Graphene Oxide Composites

• Application Summary : 3-Chloro-4-fluorophenol is used in the synthesis of a novel nonperipherally zinc (II) phthalocyanine. This compound is then used to prepare graphene oxide (GO)-based composites. These composites are studied for their sono-photochemical properties.
• Methods of Application : The zinc (II) phthalocyanine bearing 3-chloro-4-fluorophenoxy is noncovalently coated on the graphene oxide surface to prepare the composites. The photo-activity of these materials is then compared and discussed in terms of their potential ability to be used in photosensitizer in photodynamic therapy (PDT) and sono-photodynamic therapy (SPDT).
• Results or Outcomes : The study found that both the zinc (II) phthalocyanine and its composites gave very high singlet oxygen generation values in both the photochemical study (PDT) and the sono-photochemical study (SPDT). This suggests that these compounds could be promising photosensitizers for both PDT and SPDT.

Synthesis of Novel Nonperipherally Zinc (II) Phthalocyanine

• Application Summary : 3-Chloro-4-fluorophenol is used in the synthesis of a novel nonperipherally zinc (II) phthalocyanine. This compound is then used to prepare graphene oxide (GO)-based composites. These composites are studied for their sono-photochemical properties.
• Methods of Application : The zinc (II) phthalocyanine bearing 3-chloro-4-fluorophenoxy is noncovalently coated on the graphene oxide surface to prepare the composites. The photo-activity of these materials is then compared and discussed in terms of their potential ability to be used as photosensitizers in photodynamic therapy (PDT) and sono-photodynamic therapy (SPDT).
• Results or Outcomes : The study found that both the zinc (II) phthalocyanine and its composites gave very high singlet oxygen generation values in both the photochemical study (PDT) and the sono-photochemical study (SPDT). This suggests that these compounds could be promising photosensitizers for both PDT and SPDT.

Safety And Hazards

3-Chloro-4-fluorophenol is harmful if swallowed, in contact with skin, or if inhaled. It causes skin irritation, serious eye irritation, and may cause respiratory irritation. Safety measures include avoiding breathing dust/fume/gas/mist/vapors/spray, washing hands thoroughly after handling, and using only outdoors or in a well-ventilated area.

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