1214344-15-6 | 2,6-DIBROMO-4-FLUOROPYRIDINE

CAS:1214344-15-6 | 2,6-DIBROMO-4-FLUOROPYRIDINE,Description

Application in Agrochemical and Pharmaceutical Industries

• Summary of the Application: Trifluoromethylpyridine (TFMP) derivatives, which can be synthesized using 2,6-Dibromo-4-fluoropyridine, are widely used in the agrochemical and pharmaceutical industries. The major use of TFMP derivatives is in the protection of crops from pests.
• Methods of Application or Experimental Procedures: The synthesis and applications of trifluoromethylpyridine (TFMP) and its derivatives involve various chemical reactions. The specific methods and procedures would depend on the desired end product.
• Results or Outcomes: Fluazifop-butyl was the first TFMP derivative introduced to the agrochemical market, and since then, more than 20 new TFMP-containing agrochemicals have acquired ISO common names. Several TFMP derivatives are also used in the pharmaceutical and veterinary industries; five pharmaceutical and two veterinary products containing the TFMP moiety have been granted market approval, and many candidates are currently undergoing clinical trials.

Synthesis of Fluorinated Pyridines

• Summary of the Application: 2,6-Dibromo-4-fluoropyridine can be used in the synthesis of fluorinated pyridines. Fluoropyridines have reduced basicity and are usually less reactive than their chlorinated and brominated analogues. They have interesting and unusual physical, chemical, and biological properties owing to the presence of the strong electron-withdrawing substituent(s) in the aromatic ring.
• Methods of Application or Experimental Procedures: The synthesis of fluorinated pyridines involves various chemical reactions. The specific methods and procedures would depend on the desired end product. For example, fluorination of pyridine by complex AlF3 and CuF2 at 450–500°C forms a mixture of 2-fluoropyridine and 2,6-difluoropyridine.
• Results or Outcomes: Fluoropyridines are used in the search for new agricultural products having improved physical, biological, and environmental properties. About 10% of the total sales of pharmaceuticals currently used for medical treatment are drugs containing a fluorine atom.

Synthesis of Active Agrochemical and Pharmaceutical Ingredients

• Summary of the Application: Trifluoromethylpyridine (TFMP) and its derivatives, which can be synthesized using 2,6-Dibromo-4-fluoropyridine, are used in the agrochemical and pharmaceutical industries. The major use of TFMP derivatives is in the protection of crops from pests. Several TFMP derivatives are also used in the pharmaceutical and veterinary industries.
• Methods of Application or Experimental Procedures: The synthesis and applications of trifluoromethylpyridine (TFMP) and its derivatives involve various chemical reactions. The specific methods and procedures would depend on the desired end product.
• Results or Outcomes: Fluazifop-butyl was the first TFMP derivative introduced to the agrochemical market, and since then, more than 20 new TFMP-containing agrochemicals have acquired ISO common names. Five pharmaceutical and two veterinary products containing the TFMP moiety have been granted market approval, and many candidates are currently undergoing clinical trials.

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